Estrogen level fluctuations appear to play a role in alcohol use disorder in women. Reducing the number of estrogen receptors in the ventral tegmental area decreased binge drinking behaviors in female mouse models.
Dopamine D2 receptor overexpression in cholinergic interneurons of the nucleus accumbens may explain why some are more prone to cocaine addiction than others.
Researchers have identified 29 genetic variants linked to problematic alcohol use. Nineteen of the genes were previously unknown independent risk factors for alcohol use disorder.
Researchers also found preliminary evidence that ovarian hormones may modulate the differential response in women and may be related to different levels of estrogen.
A six-year-long study reveals 90% of gamers do not play in a way that is harmful or causes long-term negative outcomes. 10% of gamers develop an addiction to video gaming. Those with video gaming addiction display higher levels of depression, aggressio…
Researchers administered antibiotics to rats for two weeks, depleting their gut microbiome. They then administered oxycodone. Compared to rats given only the opioid, those given the antibiotics had profound changes in how their brains responded to the …
Cannabis use during youth enhances sensitivity to cocaine from the first exposure, a new rat study finds.
Reducing H3Q5dop in rat models of cocaine withdrawal significantly reversed cocaine mediated gene expression changes and reduced cocaine-seeking behaviors.
Using chemogenetic methods, researchers activated neurons in the anterior insular and increased prosocial behavior in rodent models of opioid addiction.